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crizotinib raises amounts of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Dose reduction could be desired for coadministered medications that are predominantly metabolized by CYP3A.Belzutifan is usually a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may well boost incidence or sever